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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7426 | ALSTERPAULLONE | Apoptosis , GSK-3 , CDK | |
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec | |||
T10096L | Voruciclib | CDK | |
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ... | |||
T2028 | NG 52 | NG52,NG-52,Compound 52 | CDK |
NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase. | |||
T7167 | Purvalanol B | NG 95 | CDK , Parasite |
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) | |||
T2059 | Purvalanol A | NG-60 | Apoptosis , CDK , Autophagy |
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. | |||
T2095 | Seliciclib | Roscovitine,R-roscovitine,CYC202 | CDK |
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM). | |||
T14914 | Cdk1/2 Inhibitor III | CDK | |
Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B. | |||
T14916 | CDK2-IN-4 | CDK | |
CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM. | |||
T5200 | Indirubin-3'-monoxime | Indirubin-3'-oxime | GSK-3 , Lipoxygenase , CDK |
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). | |||
T69188 | Aloisine B | AloisineB | GSK-3 , CDK |
Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiviral activity and can be used to study Alzheimer's, diabete... | |||
T6787 | BIO-acetoxime | BIA,GSK-3 Inhibitor X | Apoptosis , GSK-3 , HSV |
BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B. | |||
T6169 | Indirubin | Indigopurpurin,Indigo red,NSC 105327,Couroupitine B | Apoptosis , Raf , GSK-3 , CDK |
Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM. | |||
T6358 | 1-Azakenpaullone | azakenpaullone | GSK-3 |
1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. | |||
T22260 | Aminopurvalanol A | CDK | |
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... | |||
T15732 | Ribociclib succinate | LEE011 succinate | CDK |
Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex. | |||
T2679 | BMS-265246 | BMS265246 | CDK |
BMS-265246 is a potent and selective CDK1/2 inhibitor. | |||
T16359 | NU6140 | CDK , Aurora Kinase | |
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... | |||
T2247 | KenPaullone | 9-Bromopaullone,NSC-664704 | GSK-3 , CDK |
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp... | |||
T14943 | CGP60474 | VEGFR , CDK , PKC | |
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... |